Efi Stamouli was born in Thessaloniki. She graduated from the Drama School of the National Theatre of Greece (1978) and the Department of French Literature of the Aristotle University of Thessaloniki (1981). For a year (1978) she worked at the National Theatre of Greece and immediately afterwards, in 1979, she was a founding member of the Experimental Stage of "Techni", where she has remained with short breaks to this day.